In the "Whoa, we live in the future!" moment of the week, researchers at the Weill Cornell Medical College in New York City report they have identified a gene responsible for depression. Could replacing the gene cure depression?
Neuroscience Michael Kaplitt and co-author of the paper in the journal Science Translational Medicine said in a statement, "We potentially have a novel therapy to target what we now believe is one root cause of human depression."
Kaplitt's team looked at the activity of a gene called p11 in a part of the brain called the nucleus accumbens, an area responsible for feelings of reward, pleasure, and laughter. When doctors are determining whether to give a diagnosis of depression, one of the key symptoms they look for is anhedonia, or the inability to derive pleasure or satisfaction from previously-enjoyed activities.
Kaplitt's team conducted studies on depressed mice who lacked motivation to squirm away when held by their tales or pass swimming tests. When
Blog Posts by Sarah McColl, Shine staff
- Sarah McColl, Shine staff | Makeover – Thu, Oct 21, 2010 4:13 PM EDT
In the "Whoa, we live in the future!" moment of the week, researchers at the Weill Cornell Medical College in New York City report they have identified a gene responsible for depression. Could replacing the gene cure depression?Read More »from Scary or awesome? Researchers report gene therapy could cure depression
- Sarah McColl, Shine staff | Makeover – Wed, Oct 20, 2010 4:30 PM EDT
There are some questions I ask over and over of people. "What's your go-to weeknight dinner?" is a biggie. But as someone who is now and then beset with bad moods, here's another choice query: How do you fix a bad mood? Self-soothing tactics aren't just some namby-pamby way to coddle yourself. The way I see it is like this: if we don't take responsibility for our own happiness, who will?Read More »from What's your tried-and-true way to banish a bad mood?
By the time we hit adulthood, most of us don't have a mommy who will wipe away our tears with the same regularity as when we were toddlers. It's vital to know how to do this for ourselves. Not because bad moods don't have a place in our lives--they're a part of the normal emotional life cycle, for sure. In fact, research has shown that not only are bad moods natural, but that they can help you make clear-headed decisions and boost memory.
But whatever. None of that means anything when life has just come at you hard: a project lands on your desk at the eleventh hour, you get stuck in traffic, and a
- Sarah McColl, Shine staff | Work + Money – Mon, Oct 18, 2010 4:33 PM EDT
You know in Clueless when Cher challenge Tai to use one big word a day? Or when Diane Court makes a dot in the dictionary next to every word she looks up in Say Anything? These are the images that came to mind when I realized Saturday was Dictionary Day. If you're tired of using the same old words (me!), here are some easy ways to get all SAT prep on yourself and upgrade that vocab.Read More »from 5 ways to upgrade your vocabulary without sounding like a know-it-all
Make it a daily habit.
Sign up for Dictionary.com's Word of the Day. They don't just give dry definitions, they give context (which your brain needs to retain the new information), like usage from literature and current events, as well as the word's origin.
There's nothing embarrassing about not knowing something. If we couldn't admit the limits of our knowledge, we'd never learn anything! So look up the words you don't know and ask your friends what a word they used means. And you might have to ask again and again. For instance, on a particularly pleasant girl's weekend recently, apoplectic
- Sarah McColl, Shine staff | Makeover – Fri, Oct 15, 2010 3:31 PM EDT
Perhaps it's the Yankee in me--relatives who will remain unnamed have been known to pick up nickels off restaurant floors--but I was born a thrifty girl. So when the economy tanked and belts were tightened, I was already in the habit of living close to the bone. Only now I had to find new ways to cut costs that still jived with my desire to lead a life filled with daily pleasures. But cutting back at the grocery store doesn't have to mean giving up your bon vivant mantle, just a little reimagining of the way we spend, shop, and eat. Here, bloggers and smart ladies like you share some ideas.
- I've found that getting handy with baking has been a huge money-saver in our household. Homemade bread for roughly 50 cents a loaf is awesome. So are fresh batches of zucchini bread, applesauce muffins, and bar cookies. --Kristina
- [One of my biggest tricks is] Planning my menus for the entire week. When I plan ahead I can take into consideration what I have in my pantry - or what few
In my neck of the woods, we're experiencing the kind of weather that inspired Norman Rockwell's entire canon. Yesterday, I saw cute little girls in plaid coats, dogs trotting through dry leaves, and the light coming down on my dirty neighborhood sidewalk, sunny but diffuse in that quintessentially October way. Fall seems to stir up our creativity (call it a vestigial habit from our school days), and the trick of making it a part of our lives is just listening--hearing our inner creative voice (everyone has one) and letting it out. Here's how.Read More »from Stoke a creative spark in your daily life
Try a daily photo challenge. We take photos at weddings, graduations, and birthdays, but a daily photo challenge calls you to look for the beauty in your ordinary, everyday life. Looking around for just the right frame becomes not only an exercise in seeing the art of the everyday, but a simple exercise in awareness. Choose a method that works for you: digital photos, snapshots on your cell phone, polaroids, whatever. And then, if you feel really
There are those days when the solution to life's problems feels like it could be uncapped with a new lipstick. Or a lavender-scented bubble bath. Or a peppermint foot scrub. Says my friend who feels no guilt about such occasional drugstore splurges: "That's just the price of happiness today." Better still is when your beauty treat is so easy on your wallet, happiness comes free from any buyer's remorse.
Because I had spent a practically perfect weekend away with two of my favorite lady friends, of course something had to go wrong on the way home. After we lurched in stop-and-go traffic for an hour, my bus broke down on the side of the Jersey Turnpike. As we waited over an hour for a replacement bus to pick us up, some people whipped themselves into a lather. They called the bus company to demand a refund on their $12 ticket, and dialed up their credit card company to ask about traveler's insurance (do I need to tell you that call was unsuccessful?). Some passengers just complained loudly to whomever would listen. A guy seated nearby started making jokes. My seatmate turned to me as she cued up another episode of Arrested Development. "At least neither of us is traveling with a baby." In one sentence, I went from being feeling pretty zen about the whole thing to being seriously grateful the situation wasn't so much worse.Read More »from Poll: You get a flat tire. How do you deal?
My seatmate and I got the last two seats on the replacement
Something in my life has just mentally clicked over from annoying-thing-I-don't-like-about-myself to enough-is-enough-already. I'm ready for a change. But when you're familiar with that desire for things to be different but the sad reality of them, well, never actually changing, the need to set yourself up for success becomes as strong as pit bull's jaw. Here are three wise ways to make changes that stick.Read More »from How to make changes that stick
Break it into the tiniest "to do" possible
Let's say you want to have more energy. You feel ready to run one thousand errands when you eat some protein at every meal. What kind of protein do you like? Turkey sausage, you say? Write down "buy turkey sausage" on your to do list. Identify what you want in your life and then distill it down to the smallest action items. Want to run a 5k Thanksgiving morning? Download the Couch to 5k running plan. Schedule your first gym time. Lay out your workout clothes. See how easy it is to get going? When you break your goal down into small pieces
I had a thoroughly depressing realization recently: If your PMS lasts about a week, your actual period another five days--and if you're also one of the lucky few who is struck with pre-PMS, go ahead and tack on another week of cravings and mood swings--that means hormones are riding roughshod over 50% of our lives. So unfair. Here, six natural ways to deal with that half of your life. (And remember to ask your doctor before taking any supplements!)Read More »from 6 natural cures for your PMS
Studies have shown that magnesium can significantly reduce weight gain, swelling of the hands and legs, breast tenderness, and bloating. Beef up on magnesium-rich foods like legumes (soybeans, black beans and peanuts), dark leafy greens (swiss chard, spinach, kale) and seafood (salmon, halibut, oysters). And while it's hard to do when cravings are running rampant, limiting your sugar and salt intake can reduce bloating.
Whether you're PMS-ing or not, exercise is a tremendous natural mood stabilizer. If your body is
I just spent a weekend in a house with six cats, four dogs, a phone that rings every seven minutes, and a doorbell that trills twice a day. The cacophony of commotion in this house got me thinking about simplicity and how we try to create it in our lives, inspired by those silent, Zen-like photographs of orchids and a cup of green tea. Instead of fighting against the fact of our loud lives filled with kids, soccer practice, and teeth cleanings, maybe our best bet is to embrace the messiness of life. Here, five ideas how.Read More »from Learning to love the chaos
FOCUS ON WHAT YOU CAN CONTROL
Most of life is out of our control. We can't make people call or not call. We can't change the economy. We can't keep our loved ones from getting sick or keep disaster at bay. What we can control is ourselves: how kind we are, how we adapt to change, how much we smile. Doing our best work, eating food that makes us feel healthy, and how we talk to ourselves and others are all under our own domain. Even if you can only do it for one day,