The view announced this week is that the WHI studied only older women, past age 60. The menopause experts suggest that HRT appears to be safer for women in their 50's, based on their review of the scientific literature.
There is another consideration, not raised by the menopause society. The WHI studied only one variety of hormone replacement, called Prem/Pro. "Prem" stands for Premarin, estrogen made from the urine of pregnant mares (female horses). Human estrogen was not studied. "Pro" stands for medroxyprogesterone acetate, a synthetic progesterone roughly 20 times as potent as human progesterone.
Colleagues of mine with expertise in this area have long felt that study of Prem/Pro was not a sound basis for generalization to all potential varieties of HRT.
Where does this leave us? With some uncertainty about where baby ends and bathwater begins, and with bickering likely for some time to come. I think some varieties of HRT may yet prove to offer more benefit than risk. More study and scrutiny are clearly warranted. In the interim, you and your doctor will have to look carefully at pros and cons, and make a personal choice.
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