How do you move across the country safely?

Question of the year, My husband myself and my 3 young children are planning to move half way across the country back to Indiana.
Long story... making it as short as possible!!
Ok 3 years ago,my husband and I tried moving to Indiana from the East Coast. I left him for a month and a half back here we had a house. I got a job. I guess something just wasn't right something was missing. It failed I moved back here, Now we are looking to move again but we need it to work. My husband works a dead end job. Literally he does not have a chance of moving up a ladder, things are way to expensive here. I work part time for an elderly lady and own my own business. We live in a small town and anyone who ever has lived in a small town, comprehends and understands the drama involved. Yes there are good things to living in a small town but the bad outweighs the good. Failure is not an option.
So my questions are how do we move safely, and effectively across the country? Anyone who has done this must have some ideas. Do I get a job first (he is the main income provider)? Do we get a house first? We already got a moving quote. I just need a little guidance!!! People have been doing this for years but there has to be a way to do it so there is a little less stress... Please help!!